Bookmaker William Hill is offering odds of just 8/13 that the final showdown to succeed Barack Obama as US President will be between Hillary Clinton and Donald Trump.
Mrs Clinton is now a virtually unbackable 1/16 favourite with William Hill to become the Democrat candidate, while Mr Trump is 4/9 favourite to be the Republican runner.
William Hill spokesman Graham Sharpe told BetOnPolitics.co.uk: "Following the strong showings of Clinton and Trump in New York, we believe that it is an odds-on chance that the pair will fight out the final stages of the race to the White House.
Clinton is now 4/11 favourite with William Hill to be the next elected US President, with Trump the 9/2 second favourite.
“Probably the most unexpected bet for Mrs Clinton so far is a wager of 11,000 euros staked by a client from Moscow,” Sharpe added.
“That's the largest of a small, but growing, number of bets from Russian customers on the outcome – and they seem to be favouring a Democrat win.”
Meanwhile, Hill's report a late run of betting support for the Libertarian Party candidate John McAfee.
“We took a string of bets of up to £100 each for Mr McAfee at odds of 250/1, shortened him to 100/1 and took another flurry of bets, with the biggest £100, and currently offer him at 50/1,” Sharpe said.
Latest William Hill odds:
Republican candidate: 1/16 Clinton; 8/1 Sanders; 33/1 Biden
Democrat candidate: 4/9 Trump; 5/2 Cruz; 12/1 Kasich; 33/1 Ryan; 80/1 Romney
To be elected President: 4/11 Clinton; 9/2 Trump; 14/1 Sanders; 16/1 Cruz; 33/1 Kasich; 50/1 Biden; McAfee; 66/1 Ryan; 100/1 Romney.
Final two in race to White House: 8/13 Clinton- Trump; 13/5 Clinton-Cruz; 14/1 Clinton- Kasich; 14/1 Sanders- Trump; 25/1 Sanders- Cruz. Others on request.
To be Vice President: 9/4 J Castro; 5/1 E Warren; 5/1 J Kasich; 8/1 T Kaine; 9/1 C Christie; 10/1 M O'Malley; 14/1 B Sanders; 20/1 M Rubio; 20/1 S Martinez. Others on request.